Dosing and Administration

LUNESTA: Once daily, at bedtime1

Dose Range

Recommended Starting Dose: 1 mg

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1 mg

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2 mg

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3 mg
(Maximum Dose)

Tablets shown not actual size

Adults

  • Dose can be increased to 2 mg or 3 mg if clinically indicated
  • Use the lowest effective dose of LUNESTA possible for the patient
  • Total dose should not exceed 3 mg

Dosing Considerations:

  • The length of treatment should be for the minimum duration necessary for the patient
  • LUNESTA tablets must not be broken or crushed prior to ingestion
  • In some patients, the higher morning blood levels of LUNESTA following use of the 2 mg or 3 mg dose increase the risk of next day impairment of driving and other activities that require full alertness

Additional Dosing Considerations:

  • Treatment with LUNESTA should not exceed 7-10 consecutive days. Use for more than 2-3 consecutive weeks requires complete re-evaluation of the patient
  • In elderly or debilitated patients, patients with severe hepatic or renal impairment, and patients co-administered LUNESTA with potent CYP3A4 inhibitors, total dose should not exceed 2 mg
  • No dose adjustment is necessary for patients with mild-to-moderate hepatic or renal impairment
  • LUNESTA is not to be taken with alcohol
  • Taking LUNESTA with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of LUNESTA on sleep latency